Tohoku University Technology: Diagnostic Method for Primary Aldosteronism: T12-182
Adrenal venous blood samples accurately distinguish between tumor and non-tumor using HSD3B2 antibodies.
Primary aldosteronism is a condition in which steroids are autonomously oversecreted from the adrenal glands, and salt-sensitive primary aldosteronism is a disease characterized by the autonomous overproduction of steroids from the adrenal glands, which causes salt-sensitive hypertension. There are two pathological types: tumor-related (APA) and non-tumor-related (IHA), and differential diagnosis is important because the treatment methods differ (APA requires adrenalectomy, while IHA is treated with medication). Until now, no markers have been found to distinguish between APA and IHA, making differentiation difficult, as morphological characteristics were used as criteria for definitive diagnosis through pathological specimens. The inventors elucidated the 3βHSD-related steroid metabolic pathways in normal adrenal glands, IHA, and APA, and developed an evaluation method using the ratio as an indicator in adrenal venous blood samples. They also established a monoclonal antibody specific to HSD3B2, which is abundant in APA, and achieved the differentiation of the pathological conditions of APA and IHA through immunostaining by using it in combination with HSD3B1 antibody.
- Company：Tohoku Techno Arch Co., Ltd.
- Price：Other
